Activation of SIRT3 by honokiol delayed senescence and promoted alveolar bone regeneration in diabetic mice, highlighting SIRT3 as a potential therapeutic target for diabetes‐related periodontal disease.[79] Additionally, the SIRT7/ROCK1 axis regulates DPSC senescence by desuccinylating ROCK1 at K520. This evidence concerns the gene ROCK1 and diabetes mellitus.