Building on our research findings, we innovatively propose a hypothesis that METTL3 dynamically regulates circ_0001239 through m6A modification and drives the recruitment of YTH domain containing protein 2 (YTHDC2) to circ_0001239, thereby regulating KLF10 expression to aggravate Spn-induced inflammatory cascades, which may offer a new direction for treating pneumonia-associated lung injury. Here, YTHDC2 is linked to pneumonia.