GPHN and Anxiety: While it was originally proposed that IgSF9b links to Nlgn2 via S-SCAM as a bridging molecule and thereby recruits gephyrin and other GABAergic synapse components [31], we subsequently found that, at least within the amygdala anxiety circuitry, IgSF9b and Nlgn2 do not appear to act at the same synapses [32].