DICER1 and thyroid cancer, nonmedullary, 2: While bilaterality in PTC has been associated with an increased risk of central lymph node metastasis and recurrence (60, 61), we emphasise that this observation applies to the subset of PTCs studied and should not be interpreted as a generalisable feature of all DICER1-associated thyroid tumours, such as FTC or IEFVPTC (62, 63).