<h4>Background</h4>The pathogenesis of anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis)-associated seizures remains elusive.<h4>Methods</h4>Mice were injected with GluN1<sub>359-378</sub> peptide to construct a model of anti-NMDAR encephalitis. The gene discussed is GRIN1; the disease is encephalitis.