Finally, after 1 to 2 h of incubation with Mg<sup>2+</sup>-free solution, the frequency of neuronal APs following exposure to serum derived from mice receiving GluN1<sub>359-378</sub> was increased.<h4>Conclusion</h4>To the best of our knowledge, this is the first study to demonstrate that increased glutamate release may increase seizure susceptibility in patients with anti-NMDAR encephalitis. This evidence concerns the gene GRIN1 and viral encephalitis.