NTRK2 and neurodegenerative disease: Indeed, recent articles report the beneficial effects of 3-aryl isocoumarin derivatives in neurodegenerative disease via activating the neurotrophin receptor, TrkB, and attenuating the inflammation by inhibiting 5-Lipoxygenase and Prostaglandin E2 production (Ramanan et al., 2016; Sudarshan et al., 2019).