Hence, therapeutic approaches targeting the cholinergic system, such as cholinesterase inhibitors (ChEI) (Rozzini et al., 2007) aim to alleviate the cognitive symptoms in AD by increasing acetylcholine levels and enhancing cholinergic neurotransmission (Anand and Singh, 2013; Hampel et al., 2018). This evidence concerns the gene BCHE and Alzheimer disease.