Although the exact pathophysiology of PD remains incompletely understood, it is widely accepted that repetitive microvascular trauma to the tunica albuginea during sexual activity may trigger aberrant wound healing and fibrotic changes mediated by proinflammatory and profibrotic cytokines, particularly transforming growth factor-beta 1 (TGF-β1).1 This evidence concerns the gene TGFB1 and Parkinson disease.