This might be particularly true in the context of GBA1-associated PD where the impairment in the autophagy lysosomal pathway or chaperone-mediated autophagy secondary to GCase dysfunction has been repeatedly found to contribute to α-synuclein accumulation (Chatterjee and Krainc, 2023; Kuo et al., 2022). This evidence concerns the gene GBA1 and Parkinson disease.