First-phase insulin secretion (FPIS), second-phase insulin secretion (SPIS), and GE were quantified using validated models pre- and postintervention.<h4>Results</h4>Adjusting for baseline values, age, and diabetes duration, ANCOVA revealed significant between-group differences in FPIS (<i>F</i>[3, 38] = 8.64, <i>p</i> < 0.001, <i>η</i> <sup>2</sup> = 0.406), SPIS (<i>F</i>[3, 38] = 6.93, <i>p</i> < 0.001, <i>η</i> <sup>2</sup> = 0.354), and GE (<i>F</i>[3, 38] = 5.57, <i>p</i> = 0.003, <i>η</i> <sup>2</sup> = 0.305). This evidence concerns the gene INS and diabetes mellitus.