Nuclear‐cytoplasmic fractionation experiments of OE‐circSMEK1 HCC cells revealed that hnRNPK and IGF2 proteins were downregulated in both the nucleus and cytoplasm, with hnRNPK primarily distributing in the nucleus and IGF2 predominantly presenting in the cytoplasm (Figure 4E). This evidence concerns the gene HNRNPK and hepatocellular carcinoma.