Given that TRMT2A and RBM38 were identified in a prior genome‐wide shRNA screen as modifiers of circRNA abundance without affecting their linear counterparts,[23] we next performed semi‐quantitative RT‐PCR in HCC cells following knockdown of selected RNA‐binding proteins (RBPs)—SF3B4, TRMT2A, and RBM38 (Figure 5F) (TRMT2A and RBM38 were included as controls). The gene discussed is SF3B4; the disease is hepatocellular carcinoma.