We further investigated the correlation between SF3B4 and IGF2 level in HCC tissues from in Cohort 2 individuals with the lowest 20% circSMEK1 expression levels (R = 0.562, p<0.001, n = 40) (Figure 5N) as well as TCGA (R = 0.108, P = 0.036, Figure S4F, Supporting Information). Here, SF3B4 is linked to hepatocellular carcinoma.