PPP4R3A and hepatocellular carcinoma: Surprisingly, in paired adjacent and cancerous tissues of HCC, SMEK1 mRNA was significantly upregulated in the cancerous tissues (Figure S4A, Supporting Information), and this higher expression of SMEK1 was associated with the shorter OS of HCC patients (Figure S4B, Supporting Information), which is opposite to the trend observed for circSMEK1 in this study (Figure 1P).