IGF2 and hepatocellular carcinoma: As IGF2 is a secretory protein, which promotes tumor invasiveness and stemness in TME.[24] To further investigate the effects of IGF2 on TME, through TIMER database, we found that IGF2 expression was positively correlated with infiltrated cancer‐associated fibroblasts (CAFs) than rest cell types of TME in HCC (Figure6A).