Given that RNF4 maintains proteome and genome stability and that it is overexpressed in different tumor entities such as acute myeloid leukemia (AML), RNF4 may represent a vulnerability for cancer (Chang et al, 2021; Gärtner and Muller, 2014; Ding et al, 2022). Here, RNF4 is linked to acute myeloid leukemia.