Similarly, a decrease in Ang-1 and an increase in Ang-2 and the Ang-2:Ang-1 ratio have been well-documented in fatal cases of both pediatric and adult CM (Yeo et al, 2008; Lovegrove et al, 2009; Conroy et al, 2009, 2012; Jain et al, 2011). This evidence concerns the gene ANGPT2 and cutaneous mastocytosis.