While patients in frail experienced higher incidence of genital infections when they received SGLT2 inhibitors than those receiving DPP-4 inhibitors, no increases in the incidence of hypoglycemia, ketoacidosis, lower limb amputation and fractures were observed regardless of the frail status in a cohort study of 744,310 patients with type 2 diabetes aged 65 years or older [10]. The gene discussed is SLC5A2; the disease is Hypoglycemia.