PER1 and breast cancer: CRY1, PER1, and PER2 expression decreased in TNBC malignant cells compared to non-malignant cells, as shown in Fig. 5D To define the role of CRD in patient populations, we used RNA-seq data from tumors and surrounding tissues of breast cancer (BRCA) patients in the Cancer Genome Atlas (TCGA) [22] (https://github.com/Arhit-Chakrabarti/TCGA-BRCA-Analysis).