Single-cell RNAseq (scRNA-seq) (Fig. S3A) and real-time PCR (Fig. S3B) of tumor samples showed that at the time of harvesting (ZT 12 for LD mice, for CRD-induced mice, ZT was not followed), CRD did not substantially alter the expression of the clock genes, Per1, Per2, Clock, and Cry2, whereas Cry1 expression increased significantly in CRD-induced tumors (Fig. S3B). This evidence concerns the gene PER2 and neoplasm.