This result is consistent with previous reports showing that IFN-γ and TNF-α can increase the susceptibility of leukemic tumor cells to NK cell-mediated lysis through the upregulation of ICAM-1 [14, 46], the expression of which has been shown to be crucial for supporting chimeric antigen receptor (CAR)-mediated NK-cell therapies [47]. This evidence concerns the gene ICAM1 and neoplasm.