TNFRSF10B and breast cancer: We here provide evidence on the immunomodulatory effect of the combined treatment with low doses of IFN-γ + TNF-α, which significantly enhances NK cell-infiltration into 3D BC spheroids and NK cell-mediated killing of BC cells, on the one hand by increasing the expression of death receptors such as FAS and TRAIL-R2 and the adhesion molecule ICAM-1 on BC cells cultured in both 2D and 3D conditions and, on the other hand, by increasing the expression of activating receptors on NK cells infiltrating BC spheroids.