EIF4EBP1 and neoplasm: Xenografts with 4E-BP1 knockdown and xenografts with palbociclib treatment similarly had a very strong reduction of tumor growth, which correlated with a strong decrease in histologically assessable viable tumor burden as compared with respective xenografts without 4E-BP1 knockdown or palbociclib treatment (Figures 4, C and D, Supplemental Figure 4G, and Supplemental Tables 15 and 16).