PGR and neoplasm: Ki67 showed a marginal association with brain metastasis (p = 0.054), and tumor grade was a significant predictor, with intermediate differentiated tumors (G2 vs. G3) associated with a higher risk of brain metastases (p = 0.041) and brain metases are correlating with the axillary lymphnode status and the tumor sizeAlso, the absence of positive Östrogen and Progesteron receptors is a predictor in upcoming brain metastases (p < 0.001).