GLO1 and Alzheimer disease: GLO1 is a detoxifying enzyme that has been implicated in a number of diseases, such as mood disorders (55), autism (56, 57), anxiety (58, 59), schizophrenia (60, 61), diabetes (62, 63), cancer (64, 65), as well as aging (16, 66–69) and AD (17, 70–72).