However, exceptions were reported [8, 11], where a 200 kbp deletion spanning FGF14 exons 2–5 and ITGBL1 gene and a 168 kbp deletion spanning FGF14 exons 4–5 and ITGBL1 gene, respectively, did not cause cognitive impairment. This evidence concerns the gene ITGBL1 and Cognitive impairment.