Notably, despite inducing robust dural lymphangiogenesis and improving CSF tracer drainage to dCLNs, VEGF-C failed to reduce hippocampal or cortical Aβ burden, improve behavioral performance, or produce consistent morphological changes in MLVs across three different AD models (J20, APdE9, and 5xFAD, Antila et al. 2024; Da Mesquita et al. 2018). This evidence concerns the gene VEGFC and Alzheimer disease.