The GATA gene family is involved in multiple embryogenic events.5GATA4, GATA5 and GATA6 cooperate in cardiogenesis and are critical in the regulation of fetal cardiac cell specification and heart formation.6 Diseases linked to GATA4 include atrial septal defect (ASD), atrioventricular septal defect (AVSD), ventricular septal defect (VSD) and tetralogy of Fallot (OMIM:*600576). Here, GATA5 is linked to familial atrioventricular septal defect.