Particularly important is the association of SASH1 with the “Notch signaling pathway.” Given the context-dependent dual role of Notch signaling in HNSCC[24,25], the loss of SASH1 expression could lead to an imbalance in the Notch pathway, causing its aberrant activation and consequently promoting processes related to tumorigenesis and development, such as cell self-renewal, proliferation, and survival[26]. This evidence concerns the gene SASH1 and head and neck squamous cell carcinoma.