This study showed that blood glucose, insulin, HOMA-IR, TG, LDL-C, TCHO, IL-1β, TNF- α showed marked elevation in T2D mice, suggesting that there is hyperinsulinemia and IR in T2D, the body is in an inflammatory state, insulin can not be used normally, which is manifested as hyperglycemia. The gene discussed is IL1B; the disease is hyperinsulinism.