KRAS and cancer: As a member of the RAS family of proteins, KRAS encodes a GTPase that functions as a molecular switch, which transmits signals from cell surface receptors to intracellular pathways in response to external growth stimuli.1 In its unmutated, normal state, KRAS is essential for maintaining cellular homeostasis, regulating balanced cell proliferation and differentiation.2 However, mutations in the KRAS gene result in a constitutively active protein, leading to uncontrolled cell division—a hallmark of cancer.