DAZ family genes are composed of three members that is, DAZ2, Y chromosome‐linked DAZ and autosomal BOULE, which are involved in gene regulation during spermatogenesis.[7] DAZ2 (formerly named SPGY1) is related to the cross‐reacting tail protein, and it is located on sperm tails.[8] It is important to uncover the molecular mechanisms that reprogram human somatic cells to SSCs and other male germ cells, which can close the gap between male germ cells and somatic cells and offer a novel strategy to acquire phenotypic and functional spermatozoa for patients of azoospermia. The gene discussed is DAZ2; the disease is Azoospermia.