PPARGC1A and colitis: Studies have shown that TFEB partially regulates ROS homeostasis through PGC‐1α, and defects in this pathway may play a pivotal role in colitis progression.[59] PPAR‐γ is a critical anti‐inflammatory nuclear receptor that reduces the release of pro‐inflammatory cytokines by inhibiting the NF‐κB and MAPK signaling pathways.