While it has been described that the luminal papillary subtype is enriched with FGFR3 mutations, FGFR3 copy number gain, and FGFR3 overexpression,26,27,36 no previous studies have searched for associations between FGFR alterations and variant histologies in metastatic/advanced urothelial carcinomas. Here, FGFR3 is linked to urothelial carcinoma.