RNF135 and glioblastoma: We identify <i>RNF135</i> as a novel TAM-enriched gene associated with immune activation and adverse prognosis in GBM.<h4>Methods</h4>To evaluate <i>RNF135</i>'s expression profile, prognostic significance, and functional pathways, extensive transcriptome analyses from TCGA and CGGA cohorts were conducted.