Key themes include (1) a likely polygenic inheritance of moderate-risk alleles (affecting DNA repair, cell adhesion, etc.), (2) an essential role for inflammation and environment (e.g., H. pylori triggers that cause somatic mutations and epigenetic alterations), and (3) convergence on known cancer pathways (such as cell adhesion via E-cadherin, TP53 dysfunction, and signaling via RhoA, β-catenin, etc.)despite the absence of a single germline driver. Here, CDH1 is linked to cancer.