MAPK8 and fatty liver disease: We propose the first AOP for BPAF-induced hepatic steatosis: BPAF-SUCNR1 binding (MIE) → macrophage succinate release (KE1) → SUCNR1-mediated Akt inhibition/JNK activation (KE2-4) → hepatic lipid accumulation (KE5) → steatosis (AO).