Remarkably, limiting expression of the Mecp2 mutation to peripheral somatosensory neurons (i.e., not in the CNS) is sufficient to trigger the behavioral impairments and E/I imbalance in primary somatosensory cortex, but only when this expression occurs in the postnatal period; expression in adulthood produces sensory gating impairments without social impairments or anxiety-like behaviors [59]. This evidence concerns the gene MECP2 and Anxiety.