SOD1 and amyotrophic lateral sclerosis: ISO-promoted mitophagy was also quantified in nematodes using the unc-25 promoter to drive expression of DCT-1/LGG-1 in GABAergic D-type dorsal and ventral MNs of WT (control) worms (Fig. 6A) or transgenic worms co-expressing human mutant SOD1 G93A in GABAergic D-type MNs (a worm model of human ALS) (Li et al, 2014).