SQSTM1 and amyotrophic lateral sclerosis: Notably, defects in mitophagy-related genes including optineurin, p62/SQSTM1, Valosin-containing protein, and TANK-binding kinase 1 are reported to be associated with ALS (Freischmidt et al, 2017; Koppers et al, 2012; Teyssou et al, 2013; Wong and Holzbaur, 2014).