Based on our recent work showing that diet-induced weight loss improves stroke recovery in association with decreased neuroinflammation, astrocyte reactivity and reduced type 2 diabetes-induced atrophy of parvalbumin-positive interneurons, without reduction of stroke volume [13], we speculate that these cellular mechanisms are also involved after semaglutide/BI8271-induced weight loss. This evidence concerns the gene PVALB and stroke disorder.