Similar responses were observed when comparing a dose of 0.33 mg/kg (mimics mild bacteremia) versus 3 mg/kg (dose used in sepsis models) on islet gene expression, as the changes in mRNA accumulation of Gbp2, Gbp5, Defb1, Sod2, Nos2, Slc2a2, Pdx1, and Mafa appear to plateau between 0.3 to 3 mg/kg LPS (Fig. 7). The gene discussed is GBP5; the disease is bacterial infectious disease with sepsis.