LPS also does not activate NF-κB in C57BL/6 islets as assessed by IκBα degradation 30 min after LPS stimulation (Fig. 2D), nor does it stimulate Nos2, Gbp2, or Gbp5 expression by rat insulinoma INS832/13 cells (Fig. 2E). Here, GBP2 is linked to pancreatic insulinoma.