We discovered that the lncRNA EAS1 was significantly upregulated 24 h post-infection with SARS-CoV-2 across multiple models, including Calu-3, A549, ACE2-overexpressing A549 (ACE2-A549) cells and blood vessel-liver organoid (Fig. 1, A–E). This evidence concerns the gene EPB41L4A-AS1 and infection.