EPB41L4A-AS1 and infection: Hypoxia treatment markedly upregulated EAS1 expression not only in A549, HepG2, and immortalized HUVEC cells (Fig. 1, I and J), but also in primary hepatocytes, alveolar type II (AT II) cells, and primary HUVECs (Fig. 1K), identifying hypoxia as a potential driver of EAS1 overexpression during infection.