In comparison, anti-NF155 IgG4 patients commonly presented onset at a young age and benign symptoms such as tremors and no severe motor dysfunctions, which did not occur in anti-pan-NF IgG3 patients.16, 17Some patients with predominant IgG3 antibodies present with a clinical phenotype resembling GBS, characterized by ascending, symmetric proximal, and distal sensorimotor weakness. This evidence concerns the gene IGHG3 and Guillain-Barre syndrome.