PNPLA3 and cryohydrocytosis: However, the PNPLA3 G allele was not an independent factor associated with HCC risk in either the univariate analysis (OR = 1.15, 95% CI 0.63‒2.08, p = 0.65) or the multivariate analysis (OR = 0.99, 95% CI 0.49‒2.00, p = 0.98).<h4>Conclusion</h4>The PNPLA3 rs738409 polymorphism was not associated with HCC development in CHC patients with advanced fibrosis in the Brazilian population.