To assess whether HMGB2 overexpression could improve cardiac regeneration and repair in adult mice (56‐day‐old mice) following injury, we established an MI model in adult mice and injected AAV9‐cTNT‐HMGB2 or AAV9‐cTNT vector into the infarct border zone (Figure 4A). This evidence concerns the gene HMGB2 and myocardial infarction.