However, the clinical impact remains unclear.(8) The introduction of the hs-cTnI assay into clinical practice, which can distinguish small elevations of this biomarker, makes Tn increments following PCI even more controversial.(9) In the "Fourth Universal Definition of Myocardial Infarction",(10) PCI-related MI (type 4a) was subjectively denoted by an increase in Tn values of more than five times the 99th percentile upper reference limit in patients with normal baseline levels. The gene discussed is TNNI3; the disease is myocardial infarction.