PLK4 and ovarian cancer: PLK4 mRNA expression is higher in ovarian cancer tissues compared with normal ovarian tissues; in epithelial ovarian cancer, high PLK4 expression is detected in tumors of patients with the advanced pathological stage; co-expression of LIN28 homolog A (LIN28A) and PLK4 associates with poor prognosis; higher PLK4 mRNA expression levels positively correlate with more advanced clinical stages and negatively correlate with progression-free survival (PFS) and OS.