It is therefore notsurprising that dysregulation of O-GlcNAc levels is correlated withthe development of many diseases such as cancer, diabetes, neurodegeneration,and cardiovascular disorders.−, , , ,  Hence, a deeper understanding of OGT and OGA, including their proteinstructures, substrate recognition, and functional regulation, is criticalfor dissecting disease mechanisms and developing novel modulatorsfor potential therapeutic applications. The gene discussed is OGA; the disease is cancer.