Although subtle differences in the relative progression probability curves were observed (Fig. 6E; Supplementary Fig. S14), we again reject the hypothesis that complete APC loss provides maximal colorectal cancer risk, with two copies of 20AARs providing maximal risk in both POLE-deficient and MSI colorectal cancers (two 20AARs in the 95% CI of the mode, bootstrapping). Here, APC is linked to colorectal cancer.