For both cohorts, we rejected the “uniform colorectal cancer risk” hypothesis that all genotypes have the same cancer progression risk (P = 3.4 × 10−4; P = 1.2 × 10−4, respectively; Materials and Methods) and the hypothesis that maximal loss of APC provides maximal colorectal cancer risk (0 not in 95% CI of mode). This evidence concerns the gene APC and cancer.