For example, the global deletion of tandem-pore TWIK-related acid-sensitive K+ channel subunits (TASK-1 and TASK-3) depolarizes zG cells to produce autonomous Ca2+ oscillations and a prominent PA phenotype marked by elevated Aldo, low renin, and hypertension, effects that are not corrected by sodium (Na2+) loading or AngII type 1 receptor (AT1R) blockade (15, 16). This evidence concerns the gene KCNK3 and hypertensive disorder.