CDCP1 and cancer: Additionally, we investigated CUB domain-containingprotein 1 (CDCP1),which is highly overexpressed in RAS-driven cancers and undergoesectodomain cleavage by extracellular proteases on cancer cells butnot healthy cells.−,  We previously developed two antibody clones: 4A06,which targets both full-length and cleaved forms of CDCP1, and CL03,which selectively recognizes the cleaved form for enhanced tumor specificity. We found that 4A06 IgG was efficiently internalized,leading to the downregulation of both full-length and cleaved CDCP1(Figure f).