EGFR and squamous cell carcinoma: Additionally, LIPTAC1 efficiently degradedEGFR with a maximal percent degradation (Dmax) of 86%, on the EGFR high expressing epidermoid carcinoma cell lineA431 (Figure d,f).To assess the specificity of LDLR-mediated protein degradation, wetreated LDLR knockout (KO) and controlHCC1143 cells with LIPTAC1.