Initial activation of Nrf2 target genes might trigger neuroprotective processes, such as increased antioxidant defense or the unfolded protein response, which, when reaching a certain threshold, induce feedback inhibition to prevent excessive or prolonged activation, as exemplified by the Nrf2-p97-Nrf2 loop [61] and supported by the broader context of Nrf2 regulation in stroke [62]. This evidence concerns the gene NFE2L2 and stroke disorder.