Smokers with HPV-positive oropharyngeal squamous cell carcinoma exhibited poorer overall survival compared to non-smokers, particularly in cases harboring MAP3K13 amplification.39 Additionally, Ramirez-Salazar et al40 found that MGAT4A was highly elevated in C-33A cells following HPV-16 E2 expression, indicating a potential role in HPV-mediated cellular changes. Here, MAP3K13 is linked to oropharynx squamous cell carcinoma.