On the other hand, MEX3C, an RNA-binding protein, was upregulated in hepatocellular carcinoma compared to normal tissues, and its high expression correlated with poor prognosis.41MEX3C also promoted bladder carcinogenesis by modulating lipid metabolism via the c-Jun NH2-terminal kinase (JNK) pathway and could contribute to lung adenocarcinoma tumorigenesis through the ubiquitylation of RUNX Family Transcription Factor 3 (RUNX3).42CLOCK, one of the predicted target genes of HPV-associated miRNAs, may represent a novel player in HPV-associated carcinogenesis. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.