Additionally, the increased expression of hsa-miR-16 in cervical intraepithelial neoplasia and cervical cancer tissues infected with high-risk HPV was found to be consistent with HPV-16 infection.12 Furthermore, Wang et al demonstrated reduced hsa-miR-34a expression in HPV-related cervical cancer, attributed to E6-mediated p53 destabilization.28 This downregulation is attributed to the viral oncoprotein E6, which destabilizes the tumor suppressor p53, a known transactivator of hsa-miR-34a. This evidence concerns the gene TP53 and cervical carcinoma.