The α‐Cyano‐4‐hydroxycinnamic acid (CHCA) inhibits lactate transport, leading to the accumulation of lactate in tumor cells, which negatively feedback suppresses aerobic glycolysis, limits tumoral consumption of glucose, and establishes a M1 TAMs and CD4+/CD8+ T cells favorable TME with high glucose and low lactate levels, which however destabilizes Treg cells. Here, CD8A is linked to neoplasm.