Over the past decade, there has been repeatedly demonstrated that an aberrant activation of the mTOR signaling cascade may represent a pathogenic mechanism in TSC‐related epilepsy.[2, 12] mTOR is a serine–threonine protein kinase that acts through different protein complexes of mTORC1 or mTORC2.[2] These protein complexes are distinguished by composition and function.[2, 12, 16] The mTOR signaling pathway exerts a crucial role during the development of the cerebral cortex. The gene discussed is MTOR; the disease is tuberous sclerosis.