TSC2 and epilepsy: The excessive mTORC1 activation caused by loss‐of‐function of either TSC1 or TSC2 gene mutation can result in abnormal development of the cortex with alterations in neuronal and glial differentiation, neural cell size, axon and dendrite growth, and synaptogenesis.[1, 2, 17] The excessive activation of mTORC1 has been reported as the leading cause of TSC‐related epilepsy, and mTOR inhibitors can decrease the development of seizures by targeting mTORC1 (Figure 1).[8, 18] The role of mTORC2 has been less explored.