The serum level of its soluble form (sICAM‐1) serves as a prognostic biomarker for severe pancreatitis.[28] Notably, transcriptomic profiling of SFTSV‐infected pancreatic organoids revealed significant upregulation of these pro‐pancreatitis genes (C3, CSTB, ICAM1, IL1B, SQSTM1, and TNF) (Figure 2H,I), suggesting that SFTSV likely drives pancreatic injury through these conserved pathogenic pathways. Here, TNF is linked to pancreatitis.