The results provide a potential mechanism explaining the association of elevated BMP10 concentrations with heart failure events in patients.11,27,30 Pending confirmation in other models and in patients, these functional results may suggest that BMP10 could be a marker for the development of arrhythmia-induced cardiomyopathy, a condition that is probably underdiagnosed in clinical care.31 This evidence concerns the gene BMP10 and cardiac arrhythmia.